Human MANF protein

• Catalog Number: orb107776
• Category: Proteins
• Description: Mesencephalic astrocyte-derived neurotrophic factor, also known as Protein ARMET, Arginine-rich protein, MANF andARMET, is a secreted protein which belongs to the ARMET family. Recombinant human MANF produced by E. coli is a singlepolypeptide chain containing 183 amino acids (25-182) and having a molecular mass of 20.8kDa. MANF reduces endoplasmicreticulum (ER) stress and has neurotrophic effects on dopaminergic neurons. MANF has been described as a survival factor fordopaminergic neurons. MANF expression was widespread in the nervous system and non-neuronal tissues. Mature humanMANF is 99%, 98% and 96% a.a. identical to mature rat, mouse and bovine MANF respectively
• Tested applications: HPLC, SDS-PAGE
• Purity: > 95% by SDS-PAGE and HPLC analyses.
• Conjugation: Unconjugated
• MW: 18.2 kDa
• Target: MANF
• Protein Sequence: LRPGDCEVCI SYLGRFYQDL KDRDVTFSPA TIENELIKFC REARGKENRL CYYIGATDDAATKIINEVSK PLAHHIPVEK ICEKLKKKDS QICELKYDKQ IDLSTVDLKK LRVKELKKILDDWGETCKGC AEKSDYIRKI NELMPKYAPK AASARTDL
• Storage: Store at 4°C for up to two weeks. For long term storage, aliquot and store at -20°C, avoid freeze/thaw cycles.
• Buffer/Preservatives: Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.
• Alternative names: Human Mesencephalic Astrocyte-Derived Neurotrophic
• Note: For research use only
• Expiration Date: 6 months from date of receipt.

SDS-PAGE analysis of Human MANF protein