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Product Overview
| Product Name | Human Leptin tA protein |
|---|---|
| Catalog Number | orb426845 |
| Reactivity | Human |
| Conjugation | Unconjugated |
| Target | Leptin tA |
Product Properties
| Form/Appearance | White lyophilized (freeze-dried) powder. The protein was lyophilized from a concentrated (0.65mg/ml) solution with 0.003mM NaHCO3. |
|---|---|
| Storage | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Note | For research use only. |
| Purity | >98.0% as determined by: (a) Gel filtration analysis. (b) Analysis by SDS-PAGE. |
| Source | Escherichia coli. |
| Activity | Capable of inhibiting leptin-induced proliferation of BAF/3 cells stably transfected with the long form of human leptin receptor. Its in vitro activity is 6-8 fold lower than the non-pegylated antagonist but in vivo it has profound weight gain effect (as compared to the non-pegylated antagonist), resulting mainly from increased food intake. Its in vivo activity compared to that of PEG-MLA is 9-27 fold higher. |
Product Description
Recombinant of human Leptin tA protein
Solubility (25°C)
| Solubility (25°C) | It is recommended to reconstitute the lyophilized Leptin Antagonist Triple Mutant pegylated Human Recombinant in sterile 0.4% NaHCO3 adjusted to pH 8-9, not less than 100μg/ml, which can then be further diluted to other aqueous solutions. |
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