Human ILDR2 Protein

• Catalog Number: orb669286
• Category: Proteins
• Description: ILDR2 belongs to the immunoglobulin superfamily. May be involved in lipid homeostasis and ER stress pathways. ILDR2 as a novel B7-like protein with robust T cell inhibitory activity, expressed in immune cells and in immune-privileged and inflamed tissues. A fusion protein, consisting of ILDR2 extracellular domain with an Fc fragment, that binds to a putative counterpart on activated T cells showed a beneficial effect in the collagen-induced arthritis model and abrogated the production of proinflammatory cytokines and chemokines in autologous synovial-like cocultures of macrophages and cytokine-stimulated T cells. Collectively, these findings point to ILDR2 as a novel negative regulator for T cells, with potential roles in the development of immune-related diseases, including autoimmunity and cancer.
• Reactivity: Human
• Tag: C-Fc
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 45.1 kDa
• Target: ILDR2
• Protein Sequence: NP_955383.1
• Source: Human ILDR2, Fc Tag (orb669286) is expressed from human 293 cells (HEK293). It contains AA Leu 21 - Glu 186 (Accession # Q71H61-1).
• Expression System: HEK293
• Expression Region: Leu 21 - Glu 186
• Endotoxins: 1.0 EU per μg
• NCBI: NP_955383.1
• Storage: -20℃
• Buffer/Preservatives: PBS, pH7.4
• Alternative names: ILDR2,C1orf32
• Note: For research use only
• Application notes: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 45.1 kDa. The protein migrates as 45-50 kDa under reducing (R) condition (SDS-PAGE) due to Glycosylation.
• Expiration Date: 6 months from date of receipt.