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Catalog Number | orb750343 |
---|---|
Category | Proteins |
Description | Interleukin-31 receptor subunit alpha is a protein that in humans is encoded by the IL31RA gene, also known as IL-31 receptor subunit alpha, IL-31RA, GLM-R, Gp130-like receptor, CRL3, GPL. Oncostatin M receptor (OSMR) and IL31RA form the heterodimeric receptor through which IL31 signals. IL31RA is a strong activator of STAT3 and STAT5, whereas STAT1 is only marginally tyrosine-phosphorylated. dditionally, demonstrate Jak1 binding to GPL and its activation in heteromeric complexes with the OSMRbeta but also in a homomeric receptor complex. |
Reactivity | Human |
Tag | C-10×His |
Form/Appearance | Powder |
Purity | 95% |
Conjugation | Unconjugated |
MW | 59.0 kDa |
Target | IL-31 RA |
Source | Human IL-31 RA, His Tag (orb750343) is expressed from human 293 cells (HEK293). It contains AA Ala 20 - Glu 519 (Accession # Q8NI17-1). |
Expression System | HEK293 |
Biological Activity | Human IL-31, His Tagimmobilized on CM5 Chip can bind Human IL-31 RA, His Tag with an affinity constant of 52.1 nM as determined in a SPR assay (Biacore 8K) (QC tested). |
Expression Region | Ala 20 - Glu 519 |
Endotoxins | 1.0 EU per μg |
Storage | -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower. |
Buffer/Preservatives | PBS, pH7.4 |
Alternative names | IL-31 RA,IL-31RA,hGLM-R,CRL3,GPL,ZcytoR17,GLM-R,IL Read more... |
Note | For research use only |
Application notes | This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 59.0 kDa. The protein migrates as 90-110 KDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Expiration Date | 6 months from date of receipt. |
Human IL-31, His Tag immobilized on CM5 Chip can bind Human IL-31 RA, His Tag (Cat. No. orb750343) with an affinity constant of 52.1 nM as determined in a SPR assay (Biacore 8K) (QC tested).
Unconjugated | |
95% | |
83.5 kDa | |
Human IL-31 RA, Fc Tag (orb570280) is expressed from human 293 cells (HEK293). It contains AA Ala 20 - Glu 519 (Accession # Q8NI17-1). |
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