Human IL-31 RA Protein

• Catalog Number: orb570280
• Category: Proteins
• Description: Interleukin-31 receptor subunit alpha is a protein that in humans is encoded by the IL31RA gene, also known as IL-31 receptor subunit alpha, IL-31RA, GLM-R, Gp130-like receptor, CRL3, GPL. Oncostatin M receptor (OSMR) and IL31RA form the heterodimeric receptor through which IL31 signals. IL31RA is a strong activator of STAT3 and STAT5, whereas STAT1 is only marginally tyrosine-phosphorylated. dditionally, demonstrate Jak1 binding to GPL and its activation in heteromeric complexes with the OSMRbeta but also in a homomeric receptor complex.
• Reactivity: Human
• Tag: C-Fc
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 83.5 kDa
• Target: IL-31 RA
• Source: Human IL-31 RA, Fc Tag (orb570280) is expressed from human 293 cells (HEK293). It contains AA Ala 20 - Glu 519 (Accession # Q8NI17-1).
• Expression System: HEK293
• Biological Activity: Human IL-31, His Tag capture on NTA-Series S sensor chip can bind Human IL-31 RA, Fc Tag with an affinity constant of 37.1 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).
• Expression Region: Ala 20 - Glu 519
• Endotoxins: 1.0 EU per μg
• NCBI: XP_011541444.1
• Storage: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
• Buffer/Preservatives: Tris with Glycine, Arginine and NaCl, pH7.5
• Alternative names: IL-31 RA,IL-31RA,hGLM-R,CRL3,GPL,ZcytoR17,GLM-R,IL
• Note: For research use only
• Application notes: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 83.5 kDa. The protein migrates as 105-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.

Human IL-31, His Tag capture on NTA-Series S sensor chip can bind Human IL-31 RA, Fc Tag (Cat. No. orb570280) with an affinity constant of 37.1 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).