Human IL-23 R Protein

• Catalog Number: orb570286
• Category: Proteins
• Description: Interleukin 23 receptor (IL-23R) is a type I cytokine receptor, and IL-23R pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. Also, IL-23R associates constitutively with Janus kinase 2 (JAK2), and binds to transcription activator STAT3 in a ligand-dependent manner. Furthermore, IL-23R mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. As for IL-23, it may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.
• Reactivity: Human
• Tag: C-10×His
• Form/Appearance: Powder
• Purity: 90%
• Conjugation: Unconjugated
• MW: 39.9 kDa
• Target: IL-23R
• Source: Human IL-23 R, His Tag (orb570286) is expressed from human 293 cells (HEK293). It contains AA Gly 24 - Gly 355 (Accession # Q5VWK5-1).
• Expression System: HEK293
• Biological Activity: Biotinylated Human IL-23A&IL-12B Heterodimer Protein, His,&Tag Freecaptured on Biotin CAP - Series S sensor Chip can bind Human IL-23 R, His Tag (SPR verified)affinity constant of 3.39 nM as determined in a SPR assay (Biacore 8K) (QC tested).
• Expression Region: Gly 24 - Gly 355
• Endotoxins: 1.0 EU per μg
• NCBI: NP_653302.2
• Storage: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
• Buffer/Preservatives: PBS, pH7.4
• Alternative names: IL-23 R,IL-23 Receptor
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 39.9 kDa. The protein migrates as 55-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.

Biotinylated Human IL-23A & IL-12B Heterodimer Protein, His, Avitag & Tag Free captured on Biotin CAP-Series S sensor Chip can bind Human IL-23 R, His Tag (SPR verified) (Cat. No. orb570286) affinity constant of 3.39 nM as determined in a SPR assay (Biacore 8K) (QC tested).