Human IL-23 R Protein

• Catalog Number: orb570284
• Category: Proteins
• Description: Interleukin 23 receptor (IL-23R) is a type I cytokine receptor, and IL-23R pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. Also, IL-23R associates constitutively with Janus kinase 2 (JAK2), and binds to transcription activator STAT3 in a ligand-dependent manner. Furthermore, IL-23R mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. As for IL-23, it may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.
• Reactivity: Human
• Tag: C-Fc
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 64.5 kDa
• Target: IL-23R
• Source: Human IL-23 R, Fc Tag (orb570284) is expressed from human 293 cells (HEK293). It contains AA Gly 24 - Gly 355 (Accession # Q5VWK5-1).
• Expression System: HEK293
• Biological Activity: Captured Human IL-23 R, Fc Tag on CM5 chip via anti-human IgG Fc antibodies surface can bind Human IL23A & IL12B, His Tag(Routinely tested).
• Expression Region: Gly 24 - Gly 355
• Endotoxins: 1.0 EU per μg
• NCBI: NP_653302.2
• Storage: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
• Buffer/Preservatives: Tris with Glycine, Arginine and NaCl, pH7.5
• Alternative names: IL-23 R,IL-23 Receptor
• Note: For research use only
• Application notes: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 64.5 kDa. The protein migrates as 90-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.

Captured Human IL-23 R, Fc Tag (Cat. No. orb570284) on CM5 chip via anti-human IgG Fc antibodies surface can bind Human IL23A & IL12B, His Tag with an affinity constant of 5.36 nM as determined in a SPR assay (Biacore T200) (Routinely tested).