Human IL-21 R Protein

• Catalog Number: orb257628
• Category: Proteins
• Description: Interleukin-21 receptor (IL21R) is also known as CD antigen CD360, Novel interleukin receptor (NILR), is a receptor for interleukin-21 and belongs to the type I cytokine receptor family or type 4 subfamily. IL21R contains two fibronectin type-III domains. IL21R is selectively expressed in lymphoid tissues and most highly expressed in thymus and spleen. IL21R transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells.
• Reactivity: Human
• Tag: C-Fc
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 51.5 kDa
• Target: IL-21 R
• Source: Human IL-21 R, Fc Tag (orb257628) is expressed from human 293 cells (HEK293). It contains AA Cys 20 - Pro 236 (Accession # Q9HBE5-1).
• Expression System: HEK293
• Biological Activity: Human IL-21, Tag Freeimmobilized on CM5 Chip can bind Human IL-21 R, Fc Tag with an affinity constant of 0.412 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).
• Expression Region: Cys 20 - Pro 236
• Endotoxins: 1.0 EU per μg
• NCBI: NP_068570.1
• Storage: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
• Buffer/Preservatives: PBS, pH7.4
• Alternative names: IL21R,CD360,NILR
• Note: For research use only
• Application notes: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 51.5 kDa. The protein migrates as 65-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.

SDS-PAGE analysis of Human IL-21 R protein

Human IL-21, Tag Free (Cat. No. orb752328) immobilized on CM5 Chip can bind Human IL-21 R, Fc Tag (Cat. No. orb257628) with an affinity constant of 0.412 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).