Human IL-12 R beta 1 / CD212 Protein

• Catalog Number: orb570283
• Category: Proteins
• Description: The human IL-12 R subunit is a member of the cytokine receptor superfamily and the functional high-affinity IL-12R is composed of at least two beta-type cytokine receptor subunits, each independently exhibiting a low affinity for IL-12. IL-12 R beta 1 (Interleukin-12 receptor subunit beta-1) is also known as IL-12RB1, CD212. Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.
• Reactivity: Human
• Tag: C-10×His
• Form/Appearance: Powder
• Purity: 90%
• Conjugation: Unconjugated
• MW: 59.0 kDa
• Target: IL-12 R beta 1
• Source: Human IL-12 R beta 1, His Tag (orb570283) is expressed from human 293 cells (HEK293). It contains AA Cys 24 - Glu 540 (Accession # P42701-1).
• Expression System: HEK293
• Biological Activity: Immobilized Human IL-12 R beta 1, His Tag at 2 μg/mL (100 μL/well) can bind Human IL-12B, Fc Tag with a linear range of 5-156 ng/mL (QC tested).
• Expression Region: Cys 24 - Glu 540
• Endotoxins: 1.0 EU per μg
• NCBI: NP_005526.1
• Storage: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
• Buffer/Preservatives: PBS, pH7.4
• Alternative names: IL-12 R beta 1,IL12RB1,CD212,IL12R,IL12RB,IL-12RB1
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 59.0 kDa. The protein migrates as 64-68 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.

Immobilized Human IL-12 R beta 1, His Tag (Cat. No. orb570283) at 2 μg/mL (100 μL/well) can bind Human IL-12B, Fc Tag (Cat. No. orb257708) with a linear range of 5-156 ng/mL (QC tested).