Human IL-11 R alpha Protein

• Catalog Number: orb1149284
• Category: Proteins
• Description: Receptor for interleukin-11 (IL11). The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells (Probable). Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number.Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity. The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling.
• Reactivity: Human
• Tag: C-10×His
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 39.6 kDa
• Target: IL-11 R alpha
• Source: Human IL-11 R alpha, His Tag (orb1149284) is expressed from human 293 cells (HEK293). It contains AA Ser 24 - Ala 370 (Accession # Q14626-1).
• Expression System: HEK293
• Biological Activity: Loaded Biotinylated Human IL-11, His, on SA Biosensor, can bind Human IL-11 R alpha, His Tag with an affinity constant of 27 nM as determined in BLI assay (ForteBio Octet Red96e) (QC tested).
• Expression Region: Ser 24 - Ala 370
• Endotoxins: 1.0 EU per μg
• NCBI: NP_001136256.1
• Storage: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
• Buffer/Preservatives: PBS, pH7.4
• Alternative names: IL-11 R alpha,IL-11 RA,IL11RA,Interleukin-11 recep
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 39.6 kDa. The protein migrates as 47-52 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.

Loaded Biotinylated Human IL-11, His, Avitag on SA Biosensor, can bind Human IL-11 R alpha, His Tag (Cat. No. orb1149284) with an affinity constant of 27 nM as determined in BLI assay (ForteBio Octet Red96e) (QC tested).