Human IL-1 RAcP / IL-1 R3 Protein

• Catalog Number: orb257622
• Category: Proteins
• Description: Interleukin-1 receptor accessory protein (IL1RAP or IL-1RAcP) is also known as Interleukin-1 receptor 3 (IL-1R-3 or IL-1R3), C3orf13, which belongs to the interleukin-1 receptor family. IL1RAP contains three Ig-like C2-type (immunoglobulin-like) domains and one TIR domain. IL1RAP is detected in liver, skin, placenta, thymus and lung. IL-1R3 / IL1RAP is coreceptor with IL1R1, associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways.
• Reactivity: Human
• Tag: C-8×His
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 40.2 kDa
• Target: IL-1 RAcP
• Source: Human IL-1 RAcP, His Tag (orb257622) is expressed from human 293 cells (HEK293). It contains AA Ser 21 - Glu 359 (Accession # Q9NPH3).
• Expression System: HEK293
• Biological Activity: Immobilized Human Anti-IL1RAP,Human IgG1 at 1 μg/mL (100 μL/well) can bind Human IL-1 RAcP, His Tag with a linear range of 0.5-4 ng/mL (QC tested).
• Expression Region: Ser 21 - Glu 359
• Endotoxins: 1.0 EU per μg
• Storage: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
• Buffer/Preservatives: PBS, pH7.4
• Alternative names: IL1RAP,IL-1RAcP,C3orf13,IL1R3
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 40.2 kDa. The protein migrates as 50-61 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.

SDS-PAGE analysis of Human IL-1 RAcP protein

Immobilized Human Anti-IL1RAP, Human IgG1 at 1 μg/mL (100 μL/well) can bind Human IL-1 RAcP, His Tag (Cat. No. orb257622) with a linear range of 0.5-4 ng/mL (QC tested).