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Human GFR alpha-1 Protein
Catalog Number: orb257499
| Catalog Number | orb257499 |
|---|---|
| Category | Proteins |
| Description | GDNF family receptor alpha-1 (GFRA1) is also known as RET ligand 1 (RETL1), TGF-beta-related neurotrophic factor receptor 1 (TRNR1), is a novel glycosylphosphatidylinositol (GPI)-linked cell surface receptor, and belongs to the glial cell line-derived neurotrophic factor (GDNF) receptor subfamily. The GDNF family ligands comprises GDNF, Neurturin (NTN), Artemin, and Persephin. GDNF and NTN are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRA1 mediates the association with and activation of the RET tyrosine kinase receptor (RTK), and subsequently initiates the RET signaling pathway. GFR alpha-mediated signaling plays an important role in the survival, differentiation, and migration of central and peripheral neurons, and is essential for the development of kidneys and the enteric nervous system, as well as the inflammatory response in some carciniomas. |
| Reactivity | Human |
| Tag | C-10×His |
| Form/Appearance | Powder |
| Purity | 95% |
| Conjugation | Unconjugated |
| MW | 45.5 kDa |
| Target | GFR alpha-1 |
| Protein Sequence | NP_665736.1 |
| Source | Human GFR alpha-1, His Tag (orb257499) is expressed from human 293 cells (HEK293). It contains AA Asp 25 - Ser 424 (Accession # NP_665736.1). |
| Expression System | HEK293 |
| Expression Region | Asp 25 - Ser 424 |
| Endotoxins | 1.0 EU per μg |
| NCBI | NP_665736.1 |
| Storage | -20℃ |
| Buffer/Preservatives | PBS, pH7.4 |
| Alternative names | GFRA1,GDNFRA,RETL1,TRNR1,GDNFR,GFR-ALPHA-1,RET1L Read more... |
| Note | For research use only |
| Application notes | This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 45.5 kDa. The protein migrates as 55-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| Expiration Date | 6 months from date of receipt. |
SDS-PAGE analysis of Human GFR alpha-1 protein
Human GFRA1 protein [orb391794]
ELISA, MS, SDS-PAGE, WB
Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
Human cells
500 μg, 50 μg, 10 μgHuman GFRA1 protein [orb391795]
ELISA, MS, SDS-PAGE, WB
Greater than 95% as determined by reducing SDS-PAGE.
Human cells
500 μg, 50 μg, 10 μg- Item 1 of 1
Recombinant Human GFRA1 Protein, Fc Tag [orb1552325]
≥90% as determined by SDS-PAGE
This protein contains the human GFRA1(Asp25-Ser429) was fused with the C-terminal Fc Tag and expressed in Mammalian cells.
100 μg, 50 μg
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