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Human FOLR2 Protein
Catalog Number: orb257481
| Catalog Number | orb257481 |
|---|---|
| Category | Proteins |
| Description | Folate receptor beta is also known as Folate receptor 2, FBP, FOLR2, BETA-HFR, FBP/PL-1, FR-BETA, FR-P3, and is a member of the folate receptor (FOLR) family. and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. The FOLR2 protein was originally thought to exist only in placenta, but is also detected in spleen, bone marrow, and thymus. FOLR2 is predominantly expressed in placenta, cells of the neutrophilic lineage, and some CD34+ hematopoietic progenitor cells. It is upregulated on myeloid leukemias, head and neck squamous cell carcinomas, and several nonepithelial cancers. It is also upregulated on macrophages and monocytes at chronic inflammatory sites including rheumatoid arthritis synovium and glioblastoma. FOLR2 is a marker for macrophages generated in the presence of M-CSF, but not GM-CSF. Its expression correlates with increased folate uptake ability. Folate conjugates of therapeutic drugs are a potential immunotherapy tool to target tumor-associated macrophages. |
| Reactivity | Human |
| Tag | C-10×His |
| Form/Appearance | Powder |
| Purity | 90% |
| Conjugation | Unconjugated |
| MW | 26.5 kDa |
| Target | FOLR2 |
| Protein Sequence | NP_000794.3 |
| Source | Human FOLR2, His Tag (orb257481) is expressed from human 293 cells (HEK293). It contains AA Thr 17 - His 228 (Accession # P14207-1). |
| Expression System | HEK293 |
| Expression Region | Thr 17 - His 228 |
| Endotoxins | 1.0 EU per μg |
| NCBI | NP_000794.3 |
| Storage | -20℃ |
| Buffer/Preservatives | Tris and Glycine, pH7.5 |
| Alternative names | FOLR2,BETA-HFR,FBP,PL-1,FR-BETA,FR-P3,FBP Read more... |
| Note | For research use only |
| Application notes | This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 26.5 kDa. The protein migrates as 30-35 kDa under reducing (R) condition (SDS-PAGE) due to N-linked glycosylation which has been verified by PNGase F digestion. |
| Expiration Date | 6 months from date of receipt. |
SDS-PAGE analysis of Human FOLR2 protein
- Item 1 of 2
Human FOLR2 Protein, hFc Tag [orb1173743]
Unconjugated
The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
50.7 kDa
HEK293
10 μg, 100 μg, 50 μg 
Human FOLR2 protein [orb594976]
Greater than 85% as determined by SDS-PAGE.
27.1 kDa
Baculovirus
20 μg, 100 μg, 1 mg- Item 1 of 1
Human FOLR2 Protein, His Tag [orb1173809]
Unconjugated
The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.
The protein has a predicted molecular mass of 25.4 kDa after removal of the signal peptide. The apparent molecular mass of FOLR2-His is approximately 25-35 kDa due to glycosylation.
Mammalian
50 μg, 10 μg, 100 μgHuman FOLR2 Protein, mFc Tag [orb1173929]
Unconjugated
The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
The protein has a predicted molecular mass of 50.7 kDa after removal of the signal peptide.The apparent molecular mass of FOLR2-mFc is approximately 35-55 kDa due to glycosylation.
Mammalian
100 μg, 10 μg, 50 μg
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