| Category | Proteins |
|---|---|
| Catalog Number | orb511237 |
| Reactivity | Human |
| Conjugation | Unconjugated |
| MW | 19.9 kDa |
| Target | Flt-3 Ligand |
| Protein Sequence | NP_001450.2 |
| Tag | C-10×His |
| Source | Human Flt-3 Ligand, His Tag (FLL-H55H7) is expressed from Baculovirus-Insect cells. It contains AA Thr 27 - Pro 185 (Accession # P49771-1). |
| Biological origin | Human |
| Storage | -20℃ |
| Purity | 90% |
| Form/Appearance | Powder |
| Buffer/Preservatives | PBS, pH7.4 |
| Endotoxin | 1.0 EU per μg |
| Note | For research use only. |
| Expiration Date | 6 months from date of receipt. |
| Description | FMS-like tyrosine kinase 3 ligand (Flt-3 Ligand) is also known as FL, Flt3L and FLT3LG, is an α-helical cytokine that promotes the differentiation of multiple hematopoietic cell lineages. FLT3LG is expressed as a noncovalentlylinked dimer by T cells and bone marrow and thymic fibroblasts. Each 36 kDa chain carries approximately 12 kDa of N- and O- linked carbohydrates. FLT3LG is structurally homologous to stem cell factor (SCF) and colony stimulating facor 1 (CSF-1). FLT3LG acts as a growth factor that increases the number of immune cells by activating the hematopoietic progenitors. It also induces the mobilization of the hematopoietic progenitors and stem cells in vivo which may help the system to kill cancer cells. FLT3LG induces the expansion of monocytes and immature dendritic cells as well as early B cell lineage differentiation. FLT3LG cooperates with IL2, IL6, IL7, and IL15 to induce NK cell development and with IL3, IL7 and IL11 to induce terminal B cell maturation. Animal studies also show FLT3LG to reduce the severity of experimentally induced allergic inflammation. FLT3LG is crucial for steady-state pDC and cDC development. A lack of FLT3L results in low levels of DCs. |
- 1 imageHuman Flt-3 Ligand Protein [orb257476]
Human Flt-3 Ligand, premium grade (FLL-H5218) is expressed from human 293 cells (HEK293). It contains AA Thr 27 - Pro 185 (Accession # AAI26294).
18.0 kDa
95%
Unconjugated
50 μg, 1 mg, 20 μg -
- 1 imageHuman Flt-3 Ligand Protein [orb257477]
Human Flt-3 Ligand, His Tag (FLL-H5223) is expressed from human 293 cells (HEK293). It contains AA Thr 27 - Pro 185 (Accession # P49771-1).
19.9 kDa
90%
Unconjugated
1 mg, 50 μg, 20 μg -
- Human Flt3 ligand protein [orb754660]
ELISA, WB
E.Coli
16.9 kDa
Greater than 95% as determined by SDS-PAGE
50 μg, 200 μg, 1 mg, 100 μg - Human FLT3 Ligand Protein [orb1516221]
24-30 kDa
> 95% as determined by SDS-PAGE
10 μg, 50 μg, 500 μg
