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Human Flt-3 Ligand Protein

Catalog Number: orb511237

DispatchUsually dispatched within 5-10 working days
$ 3,740.00
Catalog Numberorb511237
CategoryProteins
DescriptionFMS-like tyrosine kinase 3 ligand (Flt-3 Ligand) is also known as FL, Flt3L and FLT3LG, is an α-helical cytokine that promotes the differentiation of multiple hematopoietic cell lineages. FLT3LG is expressed as a noncovalentlylinked dimer by T cells and bone marrow and thymic fibroblasts. Each 36 kDa chain carries approximately 12 kDa of N- and O- linked carbohydrates. FLT3LG is structurally homologous to stem cell factor (SCF) and colony stimulating facor 1 (CSF-1). FLT3LG acts as a growth factor that increases the number of immune cells by activating the hematopoietic progenitors. It also induces the mobilization of the hematopoietic progenitors and stem cells in vivo which may help the system to kill cancer cells. FLT3LG induces the expansion of monocytes and immature dendritic cells as well as early B cell lineage differentiation. FLT3LG cooperates with IL2, IL6, IL7, and IL15 to induce NK cell development and with IL3, IL7 and IL11 to induce terminal B cell maturation. Animal studies also show FLT3LG to reduce the severity of experimentally induced allergic inflammation. FLT3LG is crucial for steady-state pDC and cDC development. A lack of FLT3L results in low levels of DCs.
ReactivityHuman
TagC-10×His
Form/AppearancePowder
Purity90%
ConjugationUnconjugated
MW19.9 kDa
TargetFlt-3 Ligand
SourceHuman Flt-3 Ligand, His Tag (orb511237) is expressed from Baculovirus-Insect cells. It contains AA Thr 27 - Pro 185 (Accession # P49771-1).
Expression SystemInsectCells
Biological ActivityImmobilized Human Flt-3, Fc Tag at 5 μg/mL (100 μL/well) can bind Human Flt-3 Ligand, His Tag with a linear range of 0.1-1 ng/mL (QC tested).
Expression RegionThr 27 - Pro 185
Endotoxins1.0 EU per μg
NCBINP_001450.2
Storage-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Buffer/PreservativesPBS, pH7.4
Alternative namesFLT3LG,FL,FLT3L,Flt3 ligand
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NoteFor research use only
Application notesThis protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 19.9 kDa. The protein migrates as 22-28 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Expiration Date6 months from date of receipt.

Immobilized Human Flt-3, Fc Tag (Cat. No. orb570275) at 5 μg/mL (100 μL/well) can bind Human Flt-3 Ligand, His Tag (Cat. No. orb511237) with a linear range of 0.1-1 ng/mL (QC tested).

  • Human Flt-3 Ligand Protein [orb257477]

    Unconjugated

    90%

    19.9 kDa

    Human Flt-3 Ligand, His Tag (orb257477) is expressed from human 293 cells (HEK293). It contains AA Thr 27 - Pro 185 (Accession # P49771-1).

    50 μg, 1 mg
  • Human Flt-3 Ligand Protein [orb257476]

    Unconjugated

    95%

    18.0 kDa

    Human Flt-3 Ligand, premium grade (orb257476) is expressed from human 293 cells (HEK293). It contains AA Thr 27 - Pro 185 (Accession # AAI26294).

    50 μg, 20 μg, 1 mg
  • Human Flt3 ligand protein [orb754660]

    ELISA,  WB

    Greater than 95% as determined by SDS-PAGE

    16.9 kDa

    E.Coli

    100 μg, 1 mg, 200 μg, 50 μg
  • Human Flt-3 Ligand (rHuFlt-3L) [orb1495056]

    Approximately 17.6 kDa, a single non-glycosylated polypeptide chain containing 155 amino acids.

    Escherichia coli.

    10 μg, 2 μg
  • Recombinant human FLT3 Ligand protein (Active, HEK293) [orb1817179]

    > 95% as determined by SDS-PAGE

    24-30 kDa

    500 μg, 50 μg, 10 μg
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