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Human CRTAM Protein
Catalog Number: orb612121
| Catalog Number | orb612121 |
|---|---|
| Category | Proteins |
| Description | Class I-restricted T cell-associated molecule (CRTAM), a member of nectin family and the immunoglobulin superfamily, is also known as cytotoxic and regulatory T-cell molecule, which is expressed by activated CD8+ and NK T cells. CRTAM is found in spleen, thymus, small intestine, peripheral blood, and surprisingly, in brain where it is highly expressed by Purkinje cells of the cerebellum. The high affinity of CRTAM/IGSF4 adhesion allows CRTAM to disrupt IGSF4 homotypic interactions (3 - 5). IGSF4 and T cell receptor co-engagement of CRTAM-expressing CD8+ cells induces increased IFN-gamma or IL-22 production (3, 4). Furthermore, a role in cancer surveillance through NK cell-mediated rejection of IGSF4-expressing tumors has been proposed. |
| Reactivity | Human |
| Tag | C-10×His |
| Form/Appearance | Powder |
| Purity | 90% |
| Conjugation | Unconjugated |
| MW | 31.9 kDa |
| Target | CRTAM |
| Protein Sequence | NP_062550.2 |
| Source | Human CRTAM, His Tag (orb612121) is expressed from human 293 cells (HEK293). It contains AA Ser 18 - Gly 287 (Accession # O95727-1). |
| Expression System | HEK293 |
| Expression Region | Ser 18 - Gly 287 |
| Endotoxins | 1.0 EU per μg |
| NCBI | NP_062550.2 |
| Storage | -20℃ |
| Buffer/Preservatives | PBS, pH7.4 |
| Alternative names | CRTAM,CD355 Read more... |
| Note | For research use only |
| Application notes | This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 31.9 kDa. The protein migrates as 45-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| Expiration Date | 6 months from date of receipt. |
Human CRTAM Protein, His Tag [orb1173858]
Unconjugated
The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
The protein has a predicted molecular mass of 30.8 kDa after removal of the signal peptide. The apparent molecular mass of CRTAM-His is approximately 55-70 kDa due to glycosylation.
Mammalian
50 μg, 100 μg, 10 μgHuman CRTAM protein [orb391530]
ELISA, MS, SDS-PAGE, WB
Greater than 95% as determined by reducing SDS-PAGE.
Human cells
500 μg, 50 μg, 10 μgRecombinant Human CD355/CRTAM Protein, His Tag [orb1553134]
≥90% as determined by SDS-PAGE
This protein contains the human CRTAM(Met1-Ser286) was fused with the C-terminal His Tag and expressed in Mammalian cells.
100 μg, 50 μgRecombinant Human CRTAM Protein, His Tag [orb1552624]
≥90% as determined by SDS-PAGE
This protein contains the human CRTAM(Ser18-Ser286) was fused with the C-terminal His Tag and expressed in Mammalian cells.
100 μg, 50 μg
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