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Human CD46 Protein
Catalog Number: orb257285
| Catalog Number | orb257285 |
|---|---|
| Category | Proteins |
| Description | Complement regulatory protein CD46 is also known as membrane Cofactor Protein (MCP), is a type I membrane protein and is a regulatory part of the complement system. CD46 is expressed by all cells except erythrocytes. MCP acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue, and also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. In T-cells by binding to CD46, A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype. Defects in CD46 are a cause of susceptibility to hemolytic uremic syndrome atypical type 2 (AHUS2). |
| Reactivity | Human |
| Tag | C-6×His |
| Form/Appearance | Powder |
| Purity | 90% |
| Conjugation | Unconjugated |
| MW | 33.6 kDa |
| Target | CD46 |
| Protein Sequence | AAH30594.1 |
| Source | Human CD46, His Tag (orb257285) is expressed from human 293 cells (HEK293). It contains AA Cys 35 - Asp 328 (Accession # AAH30594.1). |
| Expression System | HEK293 |
| Expression Region | Cys 35 - Asp 328 |
| Endotoxins | 1.0 EU per μg |
| NCBI | AAH30594.1 |
| Storage | -20℃ |
| Buffer/Preservatives | PBS, pH7.4 |
| Alternative names | CD46,AHUS2,MCP,MIC10,TLX,TRA2.10 Read more... |
| Note | For research use only |
| Application notes | This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 33.6 kDa. The protein migrates as 45-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| Expiration Date | 6 months from date of receipt. |
SDS-PAGE analysis of Human CD46 protein
Human CD46 protein [orb624103]
Greater than 92% as determined by SDS-PAGE.
61.6 kDa
Mammalian cell
20 μg, 100 μg, 1 mg- Item 1 of 1
Human CD46 Protein, His Tag [orb689440]
Unconjugated
The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
The protein has a predicted molecular mass of 33.5 kDa after removal of the signal peptide.The apparent molecular mass of CD46-His is approximately 55-70 kDa due to glycosylation.
Mammalian
10 μg, 50 μg, 100 μgHuman CD46 protein [orb391416]
ELISA, MS, SDS-PAGE, WB
Greater than 95% as determined by reducing SDS-PAGE.
Human cells
500 μg, 50 μg, 10 μgHuman CD46 ELISA Kit [orb406835]
Human
3.12 ng/mL-200 ng/mL
0.78 ng/mL
48 t, 24T, 10 x 96 t, 96 t, 5 x 96 t
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