Human BMP-2 Protein

• Catalog Number: orb257227
• Category: Proteins
• Description: Human bone morphogenetic protein 2 (BMP2) is also known as human BMP-2, BMP-2, BMP2, BMP 2, h-BMP-2, rh-BMP-2, recombinant human BMP-2, recombinant BMP-2, BMP, is a member of the BMP subgroup belonging to the TGF-b superfamily of structurally related signaling proteins. BMP-2 is a potent osteoinductive cytokine, capable of inducing bone and cartilage formation in association with osteoconductive carriers such as collagen and synthetic hydroxyapatite. In addition to its osteogenic activity, BMP-2 plays an important role in cardiac morphogenesis and is expressed in a variety of tissues including lung, spleen, brain, liver, prostate ovary and small intestine. As implied by its name, BMPs promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. BMP2 has been demonstrated to potently induce osteoblast differentiation in a variety of cell types, and induce apoptosis in human myeloma cell lines as a novel function.
• Reactivity: Human
• Tag: Native
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 12.8 kDa
• Target: BMP-2
• Source: Human BMP-2 Protein, premium grade (orb257227) is expressed from E. coli cells. It contains AA Ala 284 - Arg 396 (Accession # NP_001191).
• Expression System: E. coli
• Biological Activity: Immobilized Human BMP-2 Protein, premium grade at 2 μg/mL (100 μL/well) can bind Human Gremlin, Fc Tag with a linear range of 1-16 ng/mL (QC tested).
• Expression Region: Ala 284 - Arg 396
• Endotoxins: 0.2 EU per μg
• NCBI: NP_001191
• Storage: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
• Buffer/Preservatives: 100 mM Acetic Acid, pH2.8
• Alternative names: BMP2,BMP2A
• Note: For research use only
• Application notes: This protein carries no "tag". The protein has a calculated MW of 12.8 kDa. the protein migrates as 14 kDa under reducing (R) condition, and 28 kDa under non-reducing (NR) condition (SDS-PAGE).
• Expiration Date: 6 months from date of receipt.

SDS-PAGE analysis of Human BMP-2 protein

Immobilized Human BMP-2 Protein, premium grade (Cat. No. orb257227) at 2 μg/mL (100 μL/well) can bind Human Gremlin, Fc Tag (Cat. No. orb18285) with a linear range of 1-16 ng/mL (QC tested).