Human Bcl-x / BCL2L1 Protein

• Catalog Number: orb257217
• Category: Proteins
• Description: Bcl-2-like protein 1 (BCL2L1), is also known as Apoptosis regulator Bcl-X (Bcl-XL). BCL2L1 / Bcl-XL is a homodimer protein and belongs to the Bcl-2 family. BCL2L1 is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. BCL2L1 is a potent inhibitor of cell death. BCL2L1 Inhibits activation of caspases. BCL2L1 appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. BCL2L1 / Bcl-XL also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.
• Reactivity: Human
• Tag: N-GST
• Form/Appearance: Powder
• Purity: 92%
• Conjugation: Unconjugated
• MW: 50.6 kDa
• Target: Bcl-x
• Protein Sequence: AAH19307
• Source: Human Bcl-x, GST Tag (orb257217) is expressed from E.coli cells. It contains AA Ser 2 - Arg 212 (Accession # AAH19307).
• Expression System: E. coli
• Expression Region: Ser 2 - Arg 212
• Endotoxins: 1.0 EU per μg
• NCBI: AAH19307
• Storage: -20℃
• Buffer/Preservatives: 20 mM Tris, 100 mM NaCl, pH7.5 with 10 mM GSH
• Alternative names: BCL2L1,Bcl-XL,Bcl2-L-1,BCL-XL,S,BCL2L,BCLX,BCLXL,B
• Note: For research use only
• Application notes: This protein carries a GST tag at the N-terminus. The protein has a calculated MW of 50.6 kDa. The protein migrates as 45-50 kDa under reducing (R) condition (SDS-PAGE).
• Expiration Date: 6 months from date of receipt.

SDS-PAGE analysis of Human Bcl-x protein