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Catalog Number | orb257216 |
---|---|
Category | Proteins |
Description | Bcl-2-like protein 1 (BCL2L1), is also known as Apoptosis regulator Bcl-X (Bcl-XL). BCL2L1 / Bcl-XL is a homodimer protein and belongs to the Bcl-2 family. BCL2L1 is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. BCL2L1 is a potent inhibitor of cell death. BCL2L1 Inhibits activation of caspases. BCL2L1 appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. BCL2L1 / Bcl-XL also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. |
Reactivity | Human |
Tag | C-6×His |
Form/Appearance | Powder |
Purity | 95% |
Conjugation | Unconjugated |
MW | 24.6 kDa |
Target | Bcl-x |
Protein Sequence | AAH19307 |
Source | Human Bcl-x, His Tag (orb257216) is expressed from E.coli cells. It contains AA Met 1 - Arg 212 (Accession # AAH19307). |
Expression System | E. coli |
Expression Region | Met 1 - Arg 212 |
Endotoxins | 1.0 EU per μg |
NCBI | AAH19307 |
Storage | -20℃ |
Buffer/Preservatives | 20 mM HEPES, 50 mM KCl, pH7.5 |
Alternative names | BCL2L1,Bcl-XL,Bcl2-L-1,BCL-XL,S,BCL2L,BCLX,BCLXL,B Read more... |
Note | For research use only |
Application notes | This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 24.6 kDa. The protein migrates as 25-27 kDa under reducing (R) condition (SDS-PAGE). |
Expiration Date | 6 months from date of receipt. |
SDS-PAGE analysis of Human Bcl-x protein
Unconjugated | |
92% | |
50.6 kDa | |
Human Bcl-x, GST Tag (orb257217) is expressed from E.coli cells. It contains AA Ser 2 - Arg 212 (Accession # AAH19307). |
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