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Catalog Number | orb511239 |
---|---|
Category | Proteins |
Description | V-set domain-containing T-cell activation inhibitor 1 (VTCN1) is also known as Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7H4, which belongs to the immunoglobulin superfamily and BTN/MOG family. VTCN1 contains two Ig-like V-type (immunoglobulin-like) domains. The expression of VTCN1 is up-regulated by IL6 and IL10 and is inhibited by GM-CSF and IL4 on antigen-presenting cells (APCs). VTCN1 / B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. VTCN1 involved in promoting epithelial cell transformation. |
Reactivity | Human |
Tag | C-Fc |
Form/Appearance | Powder |
Purity | 95% |
Conjugation | Unconjugated |
MW | 51.8 kDa |
Target | B7-H4 |
Protein Sequence | NP_078902.2 |
Source | Human B7-H4 Protein, Fc Tag (orb511239) is expressed from human 293 cells (HEK293). It contains AA Phe 29 - Ala 258 (Accession # Q7Z7D3-1). |
Expression System | HEK293 |
Expression Region | Phe 29 - Ala 258 |
Endotoxins | 0.01 EU per μg |
NCBI | NP_078902.2 |
Storage | -20℃ |
Buffer/Preservatives | PBS, pH7.4 |
Alternative names | B7-H4,VTCN1,B7S1,B7h.5 Read more... |
Note | For research use only |
Application notes | This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 51.8 kDa. The protein migrates as 66-85 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Expiration Date | 6 months from date of receipt. |
Unconjugated | |
90% | |
26.4 kDa | |
Human B7-H4, His Tag (orb257208) is expressed from human 293 cells (HEK293). It contains AA Phe 29 - Ala 258 (Accession # NP_078902). |
Unconjugated | |
The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. | |
The protein has a predicted molecular mass of 51.4 kDa after removal of the signal peptide.The apparent molecular mass of B7-H4-hFc is approximately 100-130 kDa due to glycosylation. | |
Mammalian |
Human | |
7.8 ng/mL-500 ng/mL | |
1.95 ng/mL |
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