Name: Human B7-H4 Protein
Brand: Biorbyt
SKU: orb511239

More Information
Category	Proteins
Catalog Number	orb511239
Reactivity	Human
Conjugation	Unconjugated
MW	51.8 kDa
Target	B7-H4
Protein Sequence	NP_078902.2
Tag	C-Fc
Source	Human B7-H4 Protein, Fc Tag (B74-H5256) is expressed from human 293 cells (HEK293). It contains AA Phe 29 - Ala 258 (Accession # Q7Z7D3-1).
Biological origin	Human
Storage	-20℃
Purity	95%
Form/Appearance	Powder
Buffer/Preservatives	PBS, pH7.4
Endotoxin	0.01 EU per μg
Note	For research use only.
Expiration Date	6 months from date of receipt.
Description	V-set domain-containing T-cell activation inhibitor 1 (VTCN1) is also known as Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7H4, which belongs to the immunoglobulin superfamily and BTN/MOG family. VTCN1 contains two Ig-like V-type (immunoglobulin-like) domains. The expression of VTCN1 is up-regulated by IL6 and IL10 and is inhibited by GM-CSF and IL4 on antigen-presenting cells (APCs). VTCN1 / B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. VTCN1 involved in promoting epithelial cell transformation.

Human B7-H4 Protein