Human B7-H4 Protein

• Catalog Number: orb257208
• Category: Proteins
• Description: V-set domain-containing T-cell activation inhibitor 1 (VTCN1) is also known as Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7H4, which belongs to the immunoglobulin superfamily and BTN/MOG family. VTCN1 contains two Ig-like V-type (immunoglobulin-like) domains. The expression of VTCN1 is up-regulated by IL6 and IL10 and is inhibited by GM-CSF and IL4 on antigen-presenting cells (APCs). VTCN1 / B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. VTCN1 involved in promoting epithelial cell transformation.
• Reactivity: Human
• Tag: C-8×His
• Form/Appearance: Powder
• Purity: 90%
• Conjugation: Unconjugated
• MW: 26.4 kDa
• Target: B7-H4
• Protein Sequence: NP_078902
• Source: Human B7-H4, His Tag (orb257208) is expressed from human 293 cells (HEK293). It contains AA Phe 29 - Ala 258 (Accession # NP_078902).
• Expression System: HEK293
• Expression Region: Phe 29 - Ala 258
• Endotoxins: 0.01 EU per μg
• NCBI: NP_078902
• Storage: -20℃
• Buffer/Preservatives: PBS, pH7.4
• Alternative names: B7-H4,VTCN1,B7S1,B7h.5
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 26.4 kDa. The protein migrates as 39-55 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.

SDS-PAGE analysis of Human B7-H4 protein