HPK1-IN-7

• Catalog Number: orb1089784
• Category: Small Molecules
• Description: HPK1-IN-7 is a potent, orally active HPK1 (hematopoietic progenitor kinase 1, MAP4K1) inhibitor (IC50=2.6 nM) with excellent family and kinome selectivity. HPK1-IN-7 shows selectivity against IRAK4 (59 nM) and GLK (140 nM). HPK1-IN-7 shows robust efficacy against MC38 syngeneic tumor model in combination with anti-PD1.
• CAS Number: [2320462-65-3]
• MW: 458.48
• SMILES: OC[C@@H](NC1=NC(NC2=CC(C3(C)C)=C(C(O3)=O)C=C2)=NC=C1C4=NN=CO4)C5=CC=CC=C5
• Formula: C₂₄H₂₂N₆O₄
• Note: For research use only
• Expiration Date: 12 months from date of receipt.