HP1 alpha Antibody

• Catalog Number: orb1732845
• Category: Antibodies
• Description: Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
• Species/Host: Mouse
• Clonality: Monoclonal
• Clone Number: 10B2
• Tested applications: ICC, IHC, WB
• Reactivity: Human, Mouse, Rat
• Isotype: Mouse IgG2b
• Immunogen: Purified recombinant human HP1 alpha protein fragments expressed in E.coli.
• Concentration: 1mg/ml
• Dilution range: WB: 1/500-1/1000; IHC: 1/50-1/100; ICC: 1/50-1/200
• Conjugation: Unconjugated
• MW: Calculated MW: 22 kDa; Observed MW: 26 kDa
• Entrez: 23468
• UniProt ID: P45973
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Buffer/Preservatives: Liquid in PBS containing 50% glycerol, 0.5% rAlbumin and 0.02% sodium azide, pH 7.3.
• Alternative names: CBX5; HP1A; Chromobox protein homolog 5; Antigen p
• Note: For research use only
• Expiration Date: 12 months from date of receipt.