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Product Overview
Product Name Gremlin 1 antibody
Catalog Number orb10741
Species/HostRabbit
ReactivityHuman, Mouse, Porcine, Rat
ConjugationUnconjugated
Tested applicationsICC, IF, IHC-P, WB
Immunogen KLH conjugated synthetic peptide derived from human Gremlin 1. Please contact us for the exact immunogen sequence. The peptide is available as orb12894.
Target Gremlin 1
Alternative Names
Product Properties
Form/Appearance 10 mM PBS, 0.02% sodium azide
Concentration - 100 μg (in 200 μl): 0.5 mg/ml
- 200 μg (in 400 μl): 0.5 mg/ml
Storage Store at 4°C for up to two weeks. For long term storage, aliquot and store at -20°C, avoid freeze/thaw cycles.
Note For research use only.
Isotype IgG
ClonalityPolyclonal
Purity Polyclonal antibodies are purified by peptide affinity chromatography
MW 21 kDa
Uniprot ID O60565 (Human); O70326 (Mouse); O35793 (Rat)
Entrez 26585
Product Description

Gremlin-1 (Grem1), an antagonist of bone morphogenetic proteins, is involved in fibrotic tissue formation in kidney and lung. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro) .Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed.

Application Notes
Dilution Range IF/ICC: 1:50-500, IHC-P: 1:50-500, WB: 1:200-1500
Validation Images
Immunofluorescence analysis of mouse  bone marrow tissue using Gremlin 1 antibody (dilution of primary antibody - 2.5 ug/ml)
Immunofluorescence analysis of mouse bone marrow tissue using Gremlin 1 antibody (dilution of primary antibody - 2.5 ug/ml)
Immunohistochemical staining of paraffin embedded mouse  bone marrow tissue using anti-Gremlin 1 (primary antibody at 2.5 ug/ml)
Immunohistochemical staining of paraffin embedded mouse bone marrow tissue using anti-Gremlin 1 (primary antibody at 2.5 ug/ml)
IF analysis of rat colon tissue using anti-Gremlin 1 (dilution of primary antibody at 2.5 ug/ml)
IF analysis of rat colon tissue using anti-Gremlin 1 (dilution of primary antibody at 2.5 ug/ml)
IHC-P image of pig stomach tissue using anti-Gremlin 1 (dilution of primary antibody at 2.5 ug/ml)
IHC-P image of pig stomach tissue using anti-Gremlin 1 (dilution of primary antibody at 2.5 ug/ml)
Immunofluorescence analysis of mouse  bone marrow tissue using Gremlin 1 antibody (dilution of primary antibody - 2.5 ug/ml)
Immunofluorescence analysis of mouse bone marrow tissue using Gremlin 1 antibody (dilution of primary antibody - 2.5 ug/ml)
Western blot analysis of human lung cancer (lane 1), mouse testis (lane 2), mouse spinal cord (lane 3) using Gremlin 1 antibody (1 ug/ml)
Western blot analysis of human lung cancer (lane 1), mouse testis (lane 2), mouse spinal cord (lane 3) using Gremlin 1 antibody (1 ug/ml)
IF image of rat colon tissue using anti-Gremlin 1 (primary antibody at 2.5 ug/ml)
IF image of rat colon tissue using anti-Gremlin 1 (primary antibody at 2.5 ug/ml)
Immunohistochemical staining of paraffin embedded rat pancreas tissue using anti-Gremlin 1 (primary antibody at 2.5 ug/ml)
Immunohistochemical staining of paraffin embedded rat pancreas tissue using anti-Gremlin 1 (primary antibody at 2.5 ug/ml)
IHC-P staining of rat colon tissue using Gremlin 1 antibody (dilution at 2.5 ug/ml)
IHC-P staining of rat colon tissue using Gremlin 1 antibody (dilution at 2.5 ug/ml)
Immunohistochemical staining of pig stomach tissue using anti-Gremlin 1 (dilution of primary antibody - 2.5 ug/ml)
Immunohistochemical staining of pig stomach tissue using anti-Gremlin 1 (dilution of primary antibody - 2.5 ug/ml)
Immunohistochemical staining of mouse  bone marrow tissue using Gremlin 1 antibody (dilution of primary antibody - 2.5 ug/ml)
Immunohistochemical staining of mouse bone marrow tissue using Gremlin 1 antibody (dilution of primary antibody - 2.5 ug/ml)
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