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GFR Alpha-2/GFRA2 Protein, Human, Recombinant (hFc & His)

GFR Alpha-2/GFRA2 Protein, Human, Recombinant (hFc & His)

Catalog Number: orb1961951

DispatchUsually dispatched within 5-10 working days
$ 160.00
Catalog Numberorb1961951
CategoryProteins
DescriptionGDNF family receptor alpha-2 is a glycosylphosphatidylinosito l (GPI)-linked cell surface receptor. It is part of the GDNF receptor family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor. It also able to mediate GDNF signaling through the RET tyrosine kinase receptor. It acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1.
TagC-hFc-6xHis
Purity98.00%
Protein SequenceSer22-Ser441
UniProt IDO00451
MW120 KDa (reducing condition)
Application notesReconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Expression SystemHEK293 Cells
Biological OriginHuman
Biological ActivityGDNF family receptor alpha-2 is a glycosylphosphatidylinosito l (GPI)-linked cell surface receptor. It is part of the GDNF receptor family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor. It also able to mediate GDNF signaling through the RET tyrosine kinase receptor. It acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1.
Expression RegionSer22-Ser441
Storage-20°C
NoteFor research use only