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GFR Alpha-2/GFRA2 Protein, Human, Recombinant (hFc & His)

GFR Alpha-2/GFRA2 Protein, Human, Recombinant (hFc & His)

Catalog Number: orb1961951

DispatchUsually dispatched within 5-10 working days
$ 160.00
Catalog Numberorb1961951
CategoryProteins
DescriptionGDNF family receptor alpha-2 is a glycosylphosphatidylinosito l (GPI)-linked cell surface receptor. It is part of the GDNF receptor family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor. It also able to mediate GDNF signaling through the RET tyrosine kinase receptor. It acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1.
TagC-hFc-6xHis
Purity98.00%
MW120 KDa (reducing condition)
UniProt IDO00451
Protein SequenceSer22-Ser441
Expression SystemHEK293 Cells
Biological OriginHuman
Biological ActivityGDNF family receptor alpha-2 is a glycosylphosphatidylinosito l (GPI)-linked cell surface receptor. It is part of the GDNF receptor family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor. It also able to mediate GDNF signaling through the RET tyrosine kinase receptor. It acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1.
Expression RegionSer22-Ser441
Storage-20°C
NoteFor research use only
Application notesReconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Expiration Date6 months from date of receipt.