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GAS6 Protein, Human, Recombinant (His)
Catalog Number: orb2276620
| Catalog Number | orb2276620 |
|---|---|
| Category | Proteins |
| Description | GAS6 (Growth arrest-specific protein 6) is also known as AXL receptor tyrosine kinase ligand, AXLLG, is a multimodular protein that is up-regulated by a wide variety of cell types in response to growth arrest. Gas6 binds and induces signaling through the receptor tyrosine kinases Axl, Dtk, and Mer whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. GAS6 Protein, Human, Recombinant (His) is expressed in HEK293 cells. |
| Tag | C-His |
| Purity | > 99.9% |
| UniProt ID | Q14393 |
| MW | 72.7 KDa (Predicted), 80-90 KDa (Reducing conditions) |
| Application notes | 0 |
| Expression System | HEK293 cells |
| Biological Origin | Human |
| Biological Activity | GAS6 (Growth arrest-specific protein 6) is also known as AXL receptor tyrosine kinase ligand, AXLLG, is a multimodular protein that is up-regulated by a wide variety of cell types in response to growth arrest. Gas6 binds and induces signaling through the receptor tyrosine kinases Axl, Dtk, and Mer whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. GAS6 Protein, Human, Recombinant (His) is expressed in HEK293 cells. |
| Expression Region | 0 |
| Storage | -20°C |
| Note | For research use only |
Human GAS6 Protein, His Tag [orb1173845]
The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.
The protein has a predicted molecular mass of 72.7 kDa after removal of the signal peptide. The apparent molecular mass of GAS6-His is approximately 70-100 kDa due to glycosylation.
Mammalian
10 μg, 100 μg, 50 μgRecombinant Human GAS6 Protein, N-His [orb2835349]
> 90% as determined by SDS-PAGE.
35.43 kDa
100 μg, 50 μg, 20 μgRecombinant human GAS6 Protein,C-His (HEK293) [orb2328525]
> 85% as determined by SDS-PAGE
20 μg, 50 μg, 100 μg
