Endothelin 1 Human peptide

SKU: orb216573

Description

Endothelin 1 Human peptide

Images & Validation

• Application Notes:
  Endothelin-1, a 21-amino acid peptide from vascular endothelial cells of different mammalian species, is one of the most potent vasoconstrictors. ET-1 exerts a wide variety of effects on both vascular and non-vascular (e.g. heart, lung, brain) tissues. Toxic peptides from a snake venom, the sarafotoxins, show structural and functional homology to ET-1. The role of ET-1 in clinical hypertension has been reviewed by Dhaun et al. and by Sreenivas and Oparil. ET-1 plays a central role in lung fibrosis.

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Key Properties

• Source: Synthetic
• CAS Number: 117399-94-7
• MW: 2491.95
• Purity: > 95%
• Formula: C₁₀₉H₁₅₉N₂₅O₃₂S₅
• Protein Sequence: H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-OH (Disulfide bridge Cys1-Cys15, Cys3-Cys11)

Storage & Handling

• Storage: Shipped at 4°C. Store at -20°C for one year.
• Form/Appearance: Lyophilized powder
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ET-1 (human, bovine, dog, mouse, porcine, rat)