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Catalog Number | orb216573 |
---|---|
Category | Proteins |
Description | Endothelin 1 Human peptide |
CAS Number | 117399-94-7 |
Form/Appearance | Lyophilized powder |
Purity | > 95% |
MW | 2491.95 |
Formula | C109H159N25O32S5 |
Protein Sequence | H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-OH (Disulfide bridge Cys1-Cys15, Cys3-Cys11) |
Source | Synthetic |
Storage | Shipped at 4°C. Store at -20°C for one year. |
Alternative names | Big endothelin 1 peptide, Big endothelin-1 peptide Read more... |
Note | For research use only |
Application notes | Endothelin-1, a 21-amino acid peptide from vascular endothelial cells of different mammalian species, is one of the most potent vasoconstrictors. ET-1 exerts a wide variety of effects on both vascular and non-vascular (e.g. heart, lung, brain) tissues. Toxic peptides from a snake venom, the sarafotoxins, show structural and functional homology to ET-1. The role of ET-1 in clinical hypertension has been reviewed by Dhaun et al. and by Sreenivas and Oparil. ET-1 plays a central role in lung fibrosis. |
Expiration Date | 12 months from date of receipt. |
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