DTL (N2) Antibody, Rabbit Polyclonal

• Catalog Number: orb67183
• Category: Antibodies
• Description: Rabbit polyclonal to DTL.Denticleless protein homolog (DTL) belongs to the WD repeat cdt2 family. It is a substrate-specificadapter for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cyclecontrol, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also namedCRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 andCDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure propercell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or followingUV irradiation is essential to control replication licensing. In undamaged proliferating cells, theDCX(DTL) complex promotes the 'Lys-164' monoubiquitination of PCNA to regulate PCNA-dependenttranslesion DNA synthesis.
• Clonality: Polyclonal
• Species/Host: Rabbit
• Conjugation: Unconjugated
• Reactivity: Human
• Buffer/Preservatives: 0.01% NaN3
• Purity: Affinity purification
• Immunogen: N-terminal region of human DTL
• UniProt ID: Q9NZJ0
• MW: 79
• Tested applications: WB
• Dilution range: WB:1:500-1:1000
• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Alternative names: anti-DTL antibody,anti-Denticleless protein homolo
• Research Area: Cancer, DNA Damage, Epigenetics
• Note: For research use only

Western blot analysis of total cell extracts from human Hela using DTL antibody