DNMT1 antibody

• Catalog Number: orb66726
• Category: Antibodies
• Description: Rabbit polyclonal to DNMT1.DNA (cytosine-5)-methyltransferase 1 (DNMT1) plays a role in methylating CpG residues.Preferentially methylates hemimethylated DNA and regulates tissue-specific patterns of methylatedcytosine residues. During S phase of the cell cycle DNMT1 localizes at replication sites conservingmethylation patterns in the newly synthesized strand, maintaining epigenetic inheritance. During G2and M phases of the cell cycle, DNMT1 associates with chromatin maintaining DNA methylationirrespective of replication. Atypical DNA methylation patterns have been shown to be associated withcertain human tumors and developmental abnormalities.
• Species/Host: Rabbit
• Clonality: Polyclonal
• Tested applications: WB
• Reactivity: Human, Mouse
• Immunogen: C-terminal region of human DNMT1
• Dilution range: WB:1:1000-1:5000
• Purity: Affinity purification
• Conjugation: Unconjugated
• MW: 183
• UniProt ID: P26358
• Storage: -20°C
• Buffer/Preservatives: 0.01% NaN3
• Alternative names: anti-DNMT1 antibody,anti-Cxxc9 antibody,anti-Dnmt
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

Western blot of total cell extracts from (A) mouse thymus, (B) human HeLa, (C) human Jurkat; using anti-DNMT1 (C) (orb66726) at RT for 2 h.