DKK1 antibody

• Catalog Number: orb67138
• Category: Antibodies
• Description: Rabbit polyclonal to DKK1.Dickkopf-related protein 1 (DKK1) belongs to the dickkopf family. DKK1 is a secreted protein thatinduces anterior development by antagonizing canonical Wnt signaling upstream of its effect on betacateninregulation. DKK1 inhibits LRP5/6 interaction with Wnt and by forming a ternary complex withthe transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play animportant role in vertebrate development, where they locally inhibit Wnt regulated processes such asantero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult,Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
• Species/Host: Rabbit
• Clonality: Polyclonal
• Tested applications: WB
• Reactivity: Human
• Immunogen: N-terminal region of human DKK1
• Dilution range: WB:1:500-1:1000
• Purity: Affinity purification
• Conjugation: Unconjugated
• MW: 27
• UniProt ID: O94907
• Storage: -20°C
• Buffer/Preservatives: 0.01% NaN3
• Alternative names: anti-DKK1 antibody,anti-Dickkopfrelated protein 1
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

Western blot analysis of total cell extracts from human HepG2 using DKK1 antibody