Dirithromycin

SKU: orb1224435

Description

Dirithromycin is a macrolide glycopeptide antibiotic by binding to the 50S subunit of the 70S bacterial ribosome to inhibit the translocation of peptides.(In Vitro):Dirithromycin possesses an in vitro spectrum of antimicrobial activity which is similar to that of Erythromycin.Dirithromycin exhibits excellent in vitro activity against several strains of Legionella, with MICs of ~1.0 and <0.25 μg/mL at pH=7.1 and 7.4, respectively.Dirithromycin demonstrates potent activity against several strains of Helicobacter pytori, with MICs of <0.5 μg/mL.(In Vivo):Dirithromycin (s.c. for 2 times) is effective against experimental infections caused by S. aureus, S. pyogenes, and S. pneumoniae in mice, with ED50s of 1.0, 0.6, and <0.6 mg/kg.Dirithromycin (p.o. for 2 times) is effective against experimental infections caused by S. aureus, S. pyogenes, and S. pneumoniae in mice, with ED50s of 27, 34, and 23 mg/kg.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 62013-04-1
• MW: 835.07
• Purity: >98% (HPLC)
• Formula: C₄₂H₇₈N₂O₁₄
• SMILES: CC[C@@H]1[C@](O)(C)[C@@]2([H])[C@@H](C)[C@](N[C@@H](COCCOC)O2)([H])[C@H](C)C[C@@](C)(O)[C@@](O[C@]3([H])O[C@H](C)C[C@H](N(C)C)[C@H]3O)([H])[C@@H](C)[C@H](O[C@]4([H])O[C@@H](C)[C@H](O)[C@@](OC)(C)C4)[C@@H](C)C(O1)=O
• Target: ribosome
• Solubility: Ethanol: 100 mg/mL (119.75 mM); DMSO: 11 mg/mL (13.17 mM)

Bioactivity

• In Vivo:
  Dirithromycin (s. c. for 2 times) is effective against experimental infections caused by S. aureus, S. pyogenes, and S. pneumoniae in mice, with ED50s of 1.0, 0.6, and <0.6 mg/kg. Dirithromycin (p.o. for 2 times) is effective against experimental infections caused by S. aureus, S. pyogenes, and S. pneumoniae in mice, with ED50s of 27, 34, and 23 mg/kg.
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• In Vitro:
  Dirithromycin possesses an in vitro spectrum of antimicrobial activity which is similar to that of Erythromycin. Dirithromycin exhibits excellent in vitro activity against several strains of Legionella, with MICs of ~1.0 and <0.25 μg/mL at pH=7.1 and 7.4, respectively. Dirithromycin demonstrates potent activity against several strains of Helicobacter pytori, with MICs of <0.5 μg/mL.
  Read more...

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Antibiotic AS-E 136 | LY237216

Quick Database Links

Gene Symbol

ribosome