Dirithromycin

SKU: orb1310117

Description

Dirithromycin (LY237216) is a macrolide antibiotic used in research to study its efficacy against bacterial infections like pneumonia and bronchitis. It is applied in both in vitro susceptibility testing and in vivo models of respiratory tract infections.

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 62013-04-1
• MW: 835.07
• Purity: 99.59% (May vary between batches)
• Formula: C₄₂H₇₈N₂O₁₄
• SMILES: C[C@@H]1[C@]2(O[C@H](COCCOC)N[C@]1([C@H](C)C[C@@](C)(O)[C@H](O[C@H]3[C@H](O)[C@@H](N(C)C)C[C@@H](C)O3)[C@@H](C)[C@H](O[C@H]4C[C@](OC)(C)[C@@H](O)[C@H](C)O4)[C@@H](C)C(=O)O[C@H](CC)[C@@]2(C)O)[H])[H]
• Target: ribosome,Antibacterial,Antibiotic
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:2.09 mg/mL (2.5 mM);Ethanol:93 mg/mL (111.37 mM)

Bioactivity

• In Vivo:
  At therapeutic concentrations, Dirithromycin enhances the production of IL1β in cells stimulated by lipopolysaccharides, with increases of +37% and +28% at 1 μg/mL. At supra-therapeutic concentrations, Dirithromycin inhibits IL1β through the inhibition of protein kinase C; the concentration of Dirithromycin when 50% inhibition is achieved is 378 mg/mL, while for Spiramycin it is 234 mg/mL.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Dirithromycin, Dirithromycine, Dirithromycinum, Diritromicina, 70S ribosome, 50S ribosome, Bacterial, bacteria, ASE 136, ASE136, ASE-136, Antibiotic, gram-positive, Erythromycin, inhibit, Inhibitor, macrolide, LY 237216, LY237216, LY-237216

Compound Identifiers

PubChem CID

6473883