Dicer antibody

• Catalog Number: orb150104
• Category: Antibodies
• Description: Mouse monoclonal to Dicer (RPE). Dicer is a member of the RNase III family that specifically cleaves double-stranded RNAs to generate microRNAs (miRNAs). After long primary transcript pri-miRNAs are processed to stem-looped pre-miRNAs by Drosha, pre-miRNAs are transported to the cytoplasm and further processed by Dicer to produce 22-nucleotide mature miRNAs. The mature miRNA then becomes a part of the RNA-Induced Silencing Complex (RISC) and can bind to the 3' UTR of the target mRNA..
• Species/Host: Mouse
• Clonality: Monoclonal
• Clone Number: S167-7
• Tested applications: ICC, WB
• Reactivity: Human, Mouse, Rat
• Isotype: IgG1
• Immunogen: Fusion protein amino acids 1638-1899 of mouse Endoribonuclease Dicer
• Concentration: 1 mg/ml
• Dilution range: WB (1:1000), ICC/IF (1:100)
• Conjugation: RPE
• MW: 215kDa
• Target: Dicer
• Entrez: 192119
• UniProt ID: Q8R418
• NCBI: NP_683750.2
• Storage: Conjugated antibodies should be stored at 4°C
• Buffer/Preservatives: PBS pH 7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
• Alternative names: Dicer1 antibody, DCR antibody, DCR1 antibody, DCR-
• Note: For research use only
• Application notes: 1 µg/ml of SMC-416 was sufficient for detection of Dicer in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
• Expiration Date: 12 months from date of receipt.