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Catalog Number | orb150099 |
---|---|
Category | Antibodies |
Description | Mouse monoclonal to Dicer (Biotin). Dicer is a member of the RNase III family that specifically cleaves double-stranded RNAs to generate microRNAs (miRNAs). After long primary transcript pri-miRNAs are processed to stem-looped pre-miRNAs by Drosha, pre-miRNAs are transported to the cytoplasm and further processed by Dicer to produce 22-nucleotide mature miRNAs. The mature miRNA then becomes a part of the RNA-Induced Silencing Complex (RISC) and can bind to the 3' UTR of the target mRNA.. |
Species/Host | Mouse |
Clonality | Monoclonal |
Clone Number | S167-7 |
Tested applications | ICC, WB |
Reactivity | Human, Mouse, Rat |
Isotype | IgG1 |
Immunogen | Fusion protein amino acids 1638-1899 of mouse Endoribonuclease Dicer |
Concentration | 1 mg/ml |
Dilution range | WB (1:1000), ICC/IF (1:100) |
Conjugation | Biotin |
MW | 215kDa |
Target | Dicer |
Entrez | 192119 |
UniProt ID | Q8R418 |
NCBI | NP_683750.2 |
Storage | Conjugated antibodies should be stored at 4°C |
Buffer/Preservatives | PBS pH 7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated |
Alternative names | Dicer1 antibody, DCR antibody, DCR1 antibody, DCR- Read more... |
Note | For research use only |
Application notes | 1 µg/ml of SMC-416 was sufficient for detection of Dicer in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. |
Expiration Date | 12 months from date of receipt. |
ELISA, FC, ICC, IF, WB | |
Human, Mouse | |
Rabbit | |
Polyclonal | |
Unconjugated |
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