Dengue Virus 3 (DENV3) NS3 Protein

SKU: orb1921724

Description

Dengue virus (DENV) is a single-stranded positive-sense RNA virus that causes dengue fever, belonging to the Flaviviridae family. A total of four antigenically distinct serotypes (DENV1, DENV2, DENV3 and DENV4) have been identified with different manifestations of clinical symptoms despite sharing 65% similarities. DENV non-structural protein 1 (NS1), one of the 7 non-structural proteins in DENV, is a highly conserved 48-kDa glycoprotein with serotype-specific epitopes that enable differentiation of DENV serotypes. NS1 is the only protein that is continuously secreted by infected host cells. NS1 is secreted in a hexamer form, which is composed of three dimers with a detergent-sensitive hydrophobic central cavity that carries a cargo of ～70 lipid molecules. The NS1 can be detected in the serum of patients from the onset of symptoms, which serves as a more useful diagnostic marker for the early detection of DENV. Furthermore, DENV NS1 plays a pathogenic role in vascular leakage.

Research Area

Infectious Disease & Virology

Images & Validation

• Tested Applications: CLIA

Key Properties

• Source: Dengue virus type 3 (strain ChiN/A/80-2/1980) (DENV-3)
• Expression System: Mammalian cell
• Purification: Protein A Chromatography
• MW: 40 kDa
• Purity: >95% pure (SDS-PAGE)

Storage & Handling

• Storage: For long term storage, the product should be stored at -20°C or lower.
• Form/Appearance: Purified,Liquid
• Buffer/Preservatives: PBS, 5% mannital, 0.01% Tween 80, pH7.4
• Expiration Date: 6 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DENV1 NS1