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    DC-SIGN Antibody

    Catalog Number: orb248128

    DispatchUsually dispatched within 5-10 working days
    $ 643.00
    Catalog Numberorb248128
    CategoryAntibodies
    DescriptionDC-SIGN (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin) also known as CD209, is part of the Lectin family of proteins. DC-SIGN is part of the innate immune response via its modulation of Toll-like Receptors. It is present on the surface of macrophages and dendritic cells and binds mannose carbohydrates, a class of PAMPS found on bacteria, fungi and viruses. PAMP stimulated DC-SIGN activates the Raf kinases Raf-1 and B-Raf. Raf-1 phosphorylates Ser276 of NF-kB p65 which serves as a binding site for histone acetyltransferases CREB-binding protein (CBP) and p300. Acetylation of NF-kB p65 leads to enhanced and prolonged anti-inflammatory cytokine IL-10 production.
    Species/HostRabbit
    ClonalityPolyclonal
    Tested applicationsWB
    ReactivityHuman, Mouse
    IsotypeRabbit IgG
    ImmunogenA recombinant protein fragment from human DC-SIGN was used as the immunogen for this antibody.
    Dilution rangeWestern blot: 2-5ug/ml
    PurityProtein A purified antibody
    ConjugationUnconjugated
    Formula0.5 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
    Hazard InformationThis DC-SIGN antibody is available for research use only.
    Entrez30835
    StorageAliquot the DC-SIGN antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
    Buffer/Preservatives1X PBS, pH 7.4
    NoteFor research use only
    Application notesProvided assay concentrations are suggestions only, DC-SIGN antibody titration may be required for optimal results.
    Expiration Date12 months from date of receipt.
    DC-SIGN Antibody

    Western blot testing of human samples with DC-SIGN antibody at 2 ug/ml. Predicted molecular weight ~46 kDa.

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      ELISA,  IHC,  WB

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      ELISA,  IF,  IHC-P,  WB

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      Polyclonal

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      0.1 mg, 0.02 mg
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