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DC-SIGN Antibody / CD209
Catalog Number: orb639705
| Catalog Number | orb639705 |
|---|---|
| Category | Antibodies |
| Description | DC-SIGN is a transmembrane receptor that is expressed on the surface of dendritic cells and macrophages. It is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization, which allows the receptor to bind multivalent ligands with high avidity. |
| Clonality | Recombinant |
| Species/Host | Mouse |
| Isotype | Mouse IgG1, kappa |
| Conjugation | Unconjugated |
| Reactivity | Human |
| Immunogen | A human recombinant partial protein was used as the immunogen for this recombinant CD209 antibody. |
| UniProt ID | Q9NNX6 |
| Tested applications | IHC-P |
| Dilution range | Immunohistochemistry (FFPE): 1-2ug/ml |
| Application notes | Optimal dilution of the antibody should be determined by the researcher. |
| Antibody Type | Primary Antibody |
| Clone Number | rC209/1781 |
| Formula | 0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Hazard Information | This recombinant CD209 antibody is available for research use only. |
| Note | For research use only |
IHC staining of FFPE human colon carcinoma with recombinant CD209 antibody (clone rC209/1781). HIER: boil tissue sections in pH9 10mM Tris with 1mM EDTA for 10-20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free recombinant CD209 antibody (clone rC209/1781) as confirmation of integrity and purity.
IHC staining of FFPE human colon carcinoma with recombinant CD209 antibody (clone rC209/1781). HIER: boil tissue sections in pH9 10mM Tris with 1mM EDTA for 10-20 min and allow to cool before testing.
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