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Catalog Number | orb1822896 |
---|---|
Category | Antibodies |
Description | DBC-1 (deleted in breast cancer gene 1 protein), also known as p30 DBC protein and Cell cycle and apoptosis regulator protein 2 (CCAR2), is one of the genes located within the region of chromosome 8p21.3 that is homozygously deleted in some breast cancers. DBC-1 contains a nuclear localization signal, an N-terminal leucine zipper, an EF hand and a C-terminal coiled-coil region. DBC-1 is closely related to DIS but lacks the SAP domain. During death signaling mediated by TNF-Alpha, endogenous DBC-1 undergoes caspase-dependent processing to generate DBC-1 p120 and p66, both of which include the C-terminus of the protein. Both DBC-1 p120 and p66 relocate to the cytoplasm. Overexpression of the DBC-1 p120 form results in mitochondrial clustering and matrix condensation and increases the sensitivity of cells to TNF-Alpha-mediated apoptosis. In addition, DBC-1 directly interacts with unliganded ER-Alpha, stabilizing its expression and therefore collaborating to suppress apoptosis and promote hormone-independent cell growth. |
Species/Host | Mouse |
Clonality | Monoclonal |
Clone Number | PCRP-KIAA1967-1D10 |
Tested applications | FACS, IHC-P |
Reactivity | Human |
Isotype | Mouse IgG2a |
Immunogen | Recombinant full-length human CCAR2 / KIAA1967 protein was used as the immunogen for the DBC1 antibody. |
Dilution range | Flow cytometry: 1-2ug/million cells,Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT |
Conjugation | Unconjugated |
Formula | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide |
Hazard Information | This DBC1 antibody is available for research use only. |
UniProt ID | Q8N163 |
Storage | Aliquot the DBC1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles. |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
FACS, IHC-P | |
Human | |
Mouse | |
Monoclonal | |
Unconjugated |
FACS, IHC-P | |
Human | |
Mouse | |
Monoclonal | |
Unconjugated |
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