D-K6L9

• Catalog Number: orb1674294
• Category: Proteins
• Description: Antimicrobial and anticancer peptide; Antibacterial; Antimicrobial peptides.
• Modifications: Leucines 3 and 8, and lysines 6,9 and 13 are D enantiomers, C terminal amide.
• Structure: H-Leu-Lys-(D)Leu-Leu-Lys-(D)Lys-Leu-(D)Leu-(D)Lys-Lys-Leu-Leu-(D)Lys-Leu-Leu-NH2
• Target Areas: Antibacterials
• Form/Appearance: Freeze dried solid
• Purity: > 95% by hplc
• MW: 1803.35 Da
• Formula: C₉₀H₁₇₄N₂₂O₁₅
• Solubility (25°C): Soluble in DMSO
• Protein Sequence: H-Leu-Lys-(D)Leu-Leu-Lys-(D)Lys-Leu-(D)Leu-(D)Lys-Lys-Leu-Leu-(D)Lys-Leu-Leu-NH2
• Storage: Store dry, frozen and in the dark
• Alternative names: Amphipathic 1DAM370, Amp1D, Amphipathic 1D , D-K6L
• Background: D-K6L9 is a host defense-like peptide composed of six lysines and nine leucines, modified by the inclusion of D-amino acids to improve antimicrobial activity and resistance to degradation by proteases. D-K6L9 shows antimicrobial and antibiofilm activities against Pseudomonas aeruginosa from cystic fibrosis patients without inducing bacterial resistance. In addition to its antimicrobial properties, in animal models D-K6L9 is able to target and arrest the growth of aggressive and hormone-resistant primary human prostate and breast tumours and prevent metastasis, effects which are correlated with increased necrosis of the tumour cells and a decrease in the tumour microvessel density. The selectivity of D-K6L9 derives from specific binding to surface phosphatidylserine and the killing of the cancer cells via cytoplasmic membrane depolarization.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.