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CUL3 (C) Antibody, Rabbit Polyclonal

Catalog Number: orb66953

DispatchUsually dispatched within 5-10 working days.
$ 440.00
Catalog Numberorb66953
CategoryAntibodies
DescriptionRabbit polyclonal to CUL3.CUL3 is a component of a ubiquitin E3 ligase that is essential for mitotic division. CUL3 is a corecomponent of multiple cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligasecomplexes which mediate the ubiquitination and subsequent proteasomal degradation of targetproteins. As a scaffold protein, CUL3 may contribute to catalysis through positioning of the substrateand the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex isdependent on the neddylation of the cullin subunit and is inhibited by the association of thedeneddylated cullin subunit with TIP120A/CAND1 (By similarity). BCR(SPOP) is involved inubiquitination of BMI1/PCGF4, H2AFY and DAXX, and probably GLI2 or GLI3, as well as cyclin E andof cyclin D1.
ClonalityPolyclonal
Species/HostRabbit
ConjugationUnconjugated
ReactivityHuman
Buffer/Preservatives0.01% NaN3
PurityAffinity purification
ImmunogenC-terminal region of human CUL3
UniProt IDQ13618
MW89
Tested applicationsWB
Dilution rangeWB:1:1000-1:5000
Storage-20°C
Alternative namesanti-CUL3 antibody,anti-Cullin3 antibody,anti-KIAA
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NoteFor research use only
CUL3 (C) Antibody, Rabbit Polyclonal

Western blot analysis of total cell extracts from human 293T using CUL3 antibody

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