CTOP

SKU: orb1679301

Description

This small molecule is a potent and selective μ-opioid receptor antagonist (Ki μ=0.96 nM, δ>10,000 nM). Upon central administration in vivo, it induces behavioral effects. In vitro, it also enhances potassium currents in rat locus coeruleus neurons through a mechanism independent of the μ receptor.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• Target: Opioid Receptor
• CAS Number: 103429-31-8
• MW: 1062.28
• Formula: C₅₀H₆₇N₁₁O₁₁S₂
• SMILES: C(C=1C=2C(NC1)=CC=CC2)[C@H]3NC(=O)[C@H](CC4=CC=C(O)C=C4)NC(=O)[C@@H](NC([C@@H](CC5=CC=CC=C5)N)=O)CSSC(C)(C)[C@@H](C(N[C@@H]([C@@H](C)O)C(N)=O)=O)NC(=O)[C@]([C@@H](C)O)(NC(=O)[C@H](CCCN)NC3=O)[H]

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

5311058