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CRT2 Protein, Human, Recombinant
Catalog Number: orb1961061
| Catalog Number | orb1961061 |
|---|---|
| Category | Proteins |
| Description | Calreticulin-3 belongs to the calreticulin family, members of which are calcium binding chaperones localized mainly in the endoplasmic reticulum. It can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. During spermatogenesis process, Calreticulin-3 may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Defects in CALR3 are the cause of familial hypertrophic cardiomyopathy type 19 (CMH19), it is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. |
| Tag | Tag Free |
| Purity | 98.00% |
| Protein Sequence | Thr20-Leu384 |
| UniProt ID | Q96L12 |
| MW | 40-50 KDa (reducing condition) |
| Application notes | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Expression System | E. coli |
| Biological Origin | Human |
| Biological Activity | Calreticulin-3 belongs to the calreticulin family, members of which are calcium binding chaperones localized mainly in the endoplasmic reticulum. It can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. During spermatogenesis process, Calreticulin-3 may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Defects in CALR3 are the cause of familial hypertrophic cardiomyopathy type 19 (CMH19), it is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. |
| Expression Region | Thr20-Leu384 |
| Storage | -20°C |
| Note | For research use only |
Human CALR3 protein [orb391346]
ELISA, MS, SDS-PAGE, WB
Greater than 95% as determined by reducing SDS-PAGE.
E. coli
500 μg, 50 μg, 10 μgHuman Calreticulin 3 protein [orb755824]
ELISA, WB
Greater than 95% as determined by SDS-PAGE
40 kDa
E.Coli
1 mg, 50 μg, 200 μg, 100 μgRecombinant Human Cadherin-3/CALR3 Protein, No Tag [orb1552786]
≥90% as determined by SDS-PAGE
This protein contains the human CALR3(Thr20-Leu384) was fused without Tag and expressed in E. coli.
50 μg, 100 μgHuman CALR3 Protein [orb424487]
Greater than 90.0% as determined by SDS-PAGE.
Escherichia Coli
1 mg, 5 μg, 20 μg
