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CRT0066101
Catalog Number: orb2279736
| Catalog Number | orb2279736 |
|---|---|
| Category | Small Molecules |
| Description | CRT0066101 is a PRKDs inhibitor. CRT0066101 suppressed the proliferation and migration of four bladder cancer cell lines in vitro. CRT0066101 blocked tumor growth in a mouse flank xenograft model of bladder cancer. CRT0066101 treatment or PKD2 silencing arrested bladder cancer cells at the G2/M phase, the arrest being accompanied by decreases in the levels of cyclin B1, CDK1 and phospho-CDK1 (Thr161) and increases in the levels of p27Kip1 and phospho-CDK1 (Thr14/Tyr15). CRT0066101 suppresses bladder cancer growth by inhibiting PKD2 through induction of G2/M cell cycle arrest, leading to the blockade of cell cycle progression. |
| CAS Number | [956121-30-5] |
| MW | 342.822662591934 |
| SMILES | C1(O)=CC=C(Cl)C=C1C1=NC(NC[C@H](N)CC)=C2C(=N1)C=CC=C2 |
| Formula | C18H19CLN4O |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
CRT0066101 dihydrochloride [orb1296201]
99.85%
1883545-60-5
411.33
C18H24Cl2N6O
25 mg, 5 mg, 10 mg, 50 mg, 1 mg, 1 ml x 10 mm (in DMSO)PKD-IN-1 dihydrochloride (956121-30-5 free base) [orb1298493]
99.50%
2308510-39-4
415.75
C18H21N4OCl3
50 mg, 25 mg, 5 mg, 2 mg, 1 ml x 10 mm (in DMSO), 100 mg, 10 mg
