Compound 401

• Catalog Number: orb146120
• Category: Small Molecules
• Description: Compound 401 is a cell-permeable pyrimido-isoquinolinone compound that acts as a potent, reversible, and ATP-competitive inhibitor of DNA-PK (IC50 = 280 nM) with ~19-fold selectivity over FRAP (mTOR) (IC50 = 5.3 µM).
• CAS Number: [168425-64-7]
• MW: 281.3092
• SMILES: O1C([H])([H])C([H])([H])N(C2=C([H])C(N3C([H])=C([H])C4=C([H])C([H])=C([H])C([H])=C4C3=N2)=O)C([H])([H])C1([H])[H]
• Formula: C₁₆H₁₅N₃O₂
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

Chemical structure of Compound 401