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Catalog Number | orb1993655 |
---|---|
Category | Antibodies |
Description | The CD8 T cell coreceptor (monomer approx. 32-34 kDa) is expressed as alpha/beta heterodimer on majority of MHC I-restricted conventional T cells and thymocytes and as alpha/alpha homodimer on subsets of memory T cells, intraepithelial lymphocytes, NK cells and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha-beta but not alpha-alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling. |
Clonality | Monoclonal |
Clone Number | LT8 |
Tested applications | FC |
Reactivity | Human, Primate |
Isotype | Mouse IgG1 |
Immunogen | human blood lymphocytes |
Conjugation | Pacific Blue |
Target | CD8 |
Storage | Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze. |
Buffer/Preservatives | Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
Alternative names | p32, LEU2 Read more... |
Note | For research use only |
Application notes | Flow cytometry: The reagent is designed for analysis of human blood cells using 4 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests. |
Expiration Date | 12 months from date of receipt. |
FC, IF | |
Mouse | |
Rat | |
Monoclonal | |
Pacific Blue |
FC, IF | |
Human | |
Mouse | |
Monoclonal | |
Pacific Blue |
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