CD8a Antibody (Pacific Blue)

• Catalog Number: orb1993680
• Category: Antibodies
• Description: The CD8a (CD8 alpha) subunit of CD8 T cell coreceptor is expressed in CD8 alpha/beta heterodimers on majority of MHC I-restricted conventional T cells and thymocytes and in CD8 alpha/alpha homodimers on subsets of memory T cells, intraepithelial lymphocytes, NK cells, macrophages and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha/beta but not alpha/alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.
• Clonality: Monoclonal
• Clone Number: 53-6.7
• Tested applications: FC
• Reactivity: Mouse
• Isotype: Rat IgG2a kappa
• Immunogen: Murine spleen cells
• Concentration: 0.5 mg/ml
• Conjugation: Pacific Blue
• Target: CD8a
• Entrez: 12525
• UniProt ID: P01731
• Storage: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
• Buffer/Preservatives: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• Alternative names: Ly-2, Ly-B, Ly-35, Lyt-2, BB154331
• Note: For research use only
• Application notes: Flow cytometry: Recommended dilution: 2-3 μg/ml.
• Expiration Date: 12 months from date of receipt.