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Catalog Number | orb749873 |
---|---|
Category | Antibodies |
Description | CD6 is a type I transmembrane glycoprotein that contains a 24-amino acid signal sequence, three extracellular scavenger receptor cysteine-rich (SRCR) domains, a membrane-spanning domain and a 44-amino acid cytoplasmic domain. The CD6 glycoprotein is tyrosine phosphorylated during TCR-mediated T cell activation. CD6 shows significant homology to CD5. CD6 is present on mature thymocytes, peripheral T cells and a subset of B cells. Antibodies to CD6 are used to deplete T cells from bone marrow transplants to prevent graft versus host disease. |
Species/Host | Mouse |
Clonality | Monoclonal |
Clone Number | SPV-L14 |
Tested applications | FACS, IF |
Reactivity | Human, Mouse |
Isotype | Mouse IgG1, kappa |
Immunogen | A CD8+ cytotoxic T-cell clone was used as the immunogen for the CD6 antibody. |
Dilution range | Flow cytometry: 1-2ug/ml,Immunofluorescence: 0.5-1ug/ml |
Purity | Protein G affinity chromatography |
Conjugation | Unconjugated |
Formula | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide |
Hazard Information | This CD6 antibody is available for research use only. |
UniProt ID | P30203 |
Storage | Store the CD6 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide). |
Buffer/Preservatives | 0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin (US sourced) and 0.05% sodium azide |
Note | For research use only |
Application notes | Optimal dilution of the CD6 antibody should be determined by the researcher. |
Expiration Date | 12 months from date of receipt. |
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