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Catalog Number | orb1152491 |
---|---|
Category | Antibodies |
Description | Rabbit monoclonal antibody to CD3e |
Species/Host | Mouse |
Clonality | Monoclonal |
Clone Number | 898H2-6-15 |
Tested applications | FC, IHC |
Reactivity | Porcine |
Isotype | IgG |
Immunogen | Murine antibodies were produced by immunising C3H/HeJ mice with swine peripheral blood lymphocytes. Hybridomas were generated by obtaining splenocytes from the immunised mice and fusing these with the non-Ig-producing myeloma cell line P3X63Ag8.653 via established methods. |
Concentration | 1 mg/ml |
Purity | Purified |
Conjugation | Unconjugated |
Target | CD3e |
UniProt ID | Q7YRN2 |
Storage | Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. |
Buffer/Preservatives | PBS with 0.02% Proclin 300. |
Alternative names | Leu4/T3; Cluster of Differentiation 3 epsilon chai Read more... |
Note | For research use only |
Application notes | The initial identification of 898H2-6-15 showed that it recognised the T-cell receptor-associated glycoprotein CD3, in particular the e chain (Huang et al, 1999). More recently, the 898H2-6-15 VH and VL domains were reformatted into a scFv and conjugated to diphtheria toxin (Wang et al, 2011). This version of the antibody as an 'immunotoxin' has been shown to deplete circulating T cells in swine without observation of any clinical toxicities. |
Expiration Date | 12 months from date of receipt. |
ICC, IF, IHC-P, WB | |
Guinea pig, Human, Mouse, Rat | |
Rabbit | |
Polyclonal | |
Unconjugated |
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