CD3 zeta Antibody (FITC)

• Catalog Number: orb1993780
• Category: Antibodies
• Description: CD3 complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta (CD247). These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation.
• Clonality: Monoclonal
• Clone Number: H146-968
• Tested applications: FC
• Reactivity: Human, Mouse
• Isotype: Armenian Hamster IgG2 kappa
• Immunogen: Synthetic peptide corresponding to amino acids 151-164 of mouse CD3 zeta.
• Concentration: 1 mg/ml
• Conjugation: FITC
• Target: CD3 zeta
• Entrez: 919
• UniProt ID: P20963
• Storage: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
• Buffer/Preservatives: Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide
• Alternative names: CD3 zeta chain, CD247, T3Z, TCRz, IMD25
• Note: For research use only
• Application notes: Flow cytometry: Recommended dilution: 1-4 μg/ml. Intracellular staining.
• Expiration Date: 12 months from date of receipt.