CD11a antibody

• Catalog Number: orb348923
• Category: Antibodies
• Description: Rabbit monoclonal antibody to CD11a
• Species/Host: Human
• Clonality: Monoclonal
• Clone Number: hu1124 (Efalizumab)
• Tested applications: Blocking, FC
• Reactivity: Human
• Isotype: IgG
• Immunogen: Efalizumab binds to CD11a, a subunit of leukocyte function antigen-1 (LFA-1), which is expressed on all leukocytes.
• Concentration: 1 mg/ml
• Purity: Purified
• Conjugation: Unconjugated
• Target: CD11a
• UniProt ID: P20701
• Storage: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
• Buffer/Preservatives: PBS with 0.02% Proclin 300.
• Alternative names: LFA-1; integrin alpha L
• Note: For research use only
• Application notes: Efalizumab binds to the LFA-1 alpha I domain blocking the ICAM-1 binding site via steric hindrance.
• Expiration Date: 12 months from date of receipt.

References

Bauer, R. J. et al. Population pharmacokinetics and pharmacodynamics of the anti-CD11a antibody hu1124 in human subjects with psoriasis J Pharmacokinet Biopharm, 27, 397-420 (1999)

PubMed: 10826130

Reactivity

Human